Not a real patient

A CLEAR CHOICE for Acne Management

Learn why AKLIEF (trifarotene) Cream, 0.005% acne treatment may be right for you.1

Rapid and robust acne clearance

AKLIEF (trifarotene) Cream, 0.005% is FDA-approved to treat acne vulgaris on the face, back, shoulders, and chest in people 9 years of age and older.¹ With significant visible results reported as early as 2 weeks,² AKLIEF Cream treats acne while helping to prevent and reduce the visible effects that breakouts can leave behind.3abcd

Week 1

Noticeable improvement acne on the face.2ab

Week 2

Significant improvement in acne on the chest, shoulders, and back.2ab

Week 8

50% reduction in acne on the face with clearer skin and fewer breakouts.2ab

See real results

AKLIEF Cream improved acne, acne-induced scarring and dark marks

In addition to helping clear active acne, studies show AKLIEF Cream may help to prevent and improve the appearance of acne scars and acne-induced dark marks (post-inflammatory hyperpigmentation, PIH)* that can remain after breakouts.3,4abcd

Acne scarring

People with acne using AKLIEF Cream saw significant reduction of acne scars as early as 2 weeks, achieving over 55% fewer scars by Week 24.3c   

See Real Results

Acne induced dark marks

People with acne using AKLIEF Cream saw visible decrease in dark marks (PIH) within 12 weeks with continued improvement at Weeks 20–24.4cd

See Real Results

How AKLIEF Cream works

AKLIEF Cream contains trifarotene, the newest retinoid FDA approved for acne.5 It works by helping your skin shed dead skin cells, reducing inflammation, and supporting the skin's natural renewal process.5,6 By targeting acne at its source, AKLIEF Cream helps clear existing breakouts and may also improve the appearance of post-acne marks, including PIH and acne scars over time.3,4abcd

A modern acne treatment with a skincare feel

AKLIEF Cream delivers low-concentration triferotene in a smooth, moisturizing cream base with ingredients to condition the skin.1 Patients on AKLIEF Cream state that it spreads easily, absorbs quickly, and feels comfortable on the skin7. AKLIEF Cream is safe and effective for all skin tones and types while being gentle enough for long-term daily use.2,8 

100%

of patients satisfied with AKLIEF Cream ease of use

90%

noted cosmetic qualities supported consistent application.⁷

>95%

of users AKLIEF Cream spreads easily and absorbs quickly without feeling greasy or oily.⁷ 

Hear from a real AKLIEF Cream patient 

Acne doesn't just affect teenagers. AKLIEF Cream is safe for all skin types and tones and can be used by pre-teens, teens, and adults.1,5 Hear directly from a patient about their AKLIEF Cream experience and results.  

A real patient’s experience with AKLIEF Cream

AKLIEF Cream use in moderate to severe acne

AKLIEF Cream can be used alone or in combination with other acne treatments when recommended by a healthcare provider.⁹ In a clinical study of combination therapy (AKLIEF Cream plus oral doxycycline), patients with severe acne experienced up to a 95% reduction in acne lesions after 12 weeks.9,10ab

Talk to your healthcare provider about the treatment approach that may be right for you.

See Real Results

Why patients choose AKLIEF Cream

Acne is more than just breakouts. It can leave marks, affect confidence, and show up on multiple areas of the body.¹¹ AKLIEF Cream is designed to help clear acne and helping to reduce and prevent long-term visible impacts acne can leave behind.3,4,11abcd

Targets acne, improving acne scars and dark marks

Proven to clear active acne which significantly reduced acne and scarring simultaneously.3,abc

Treats acne wherever it appears

Acne isn’t limited to the face. Over 69% of people with facial acne also have acne on their chest, back, or shoulders.13 AKLIEF Cream is FDA approved  to treat both facial and truncal acne, helping address acne wherever it shows up.1ab

Great feel and easy to use

AKLIEF Cream features a proprietary formulation that delivers active ingredient in a moisturizing cream designed for daily use. Formulated with ingredients that help support the skin barrier and maintain skin comfort, it can fit seamlessly into a skincare routine, while effectively treating acne.7ab

Safe for all skin types and tones

Proven safe for diverse skin tones and types and gentle enough for long-term daily use1,2,3

See Results Now

a. Studied in acne patients from 9 to 58 years of age with diverse skin types and moderate-to-severe acne. Nodulocystic acne was excluded from the trials.

b. Significant improvement seen as early as Week 1 in the pivotal clinical trials.

c. Secondary to clearing acne.

d. The primary endpoint was the overall disease severity score (ODS). No statistical significance between AKLIEF Cream and vehicle at Week 24 was seen.

References

  1. AKLIEF (trifarotene) Cream, 0.005% Prescribing Information. Dallas, TX: Galderma Laboratories, L.P.
  2. Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol. 2019;80(6):1691–1699.
  3. Schleicher S, et al. Trifarotene reduces risk for atrophic acne scars: Results from a phase 4 controlled study. Dermatol Ther (Heidelb). 2023;13(12):3085–3096.
  4. Alexis A, et al. Trifarotene for acne-induced post-inflammatory hyperpigmentation. Int J Dermatol. 2024;63(6):806–815.
  5. Aubert J, et al. Trifarotene: Development of a potent and selective RAR-γ agonist for topical treatment of acne. Br J Dermatol. 2018;179(2):442–456.
  6. Thoreau E, et al. Retinoic acid receptor-γ selective agonists: medicinal chemistry and pharmacology. Bioorg Med Chem Lett. 2018;28(10):1736–1741.
  7. RD.06.SRE.202394 Clinical Study (DUAL study). Galderma. Data on file. Dallas, TX: Galderma Laboratories, L.P.
  8. Blume-Peytavi U, et al. Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne. J Eur Acad Dermatol Venereol. 2020;34(1):166–173.
  9. Management of Acne Vulgaris With Trifarotene (DUAL combination therapy overview). Tan J, et al. (bibliographic details not provided).
  10. Galderma. Clinical Study Report RD.06.SRE.18252. Dallas, TX: Galderma Laboratories, L.P.
  11. Layton A, et al. Long-term impact of acne and treatment outcomes on quality of life. JAAD Int. 2021;5:41–48.
  12. Del Rosso JQ, et al. J Drugs Dermatol. 2007;6(6):597–600.
  13. Tan J, et al. Acne burden and patient-reported outcomes. JAAD Int. 2021;6:43–50.

IMPORTANT SAFETY INFORMATION

Indication: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Warnings/Precautions: Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning. Use a moisturizer from the initiation of treatment, and, if appropriate, depending upon the severity of these adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream. Minimize exposure to sunlight and sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.