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A CLEAR CHOICE for Visible Results

Explore real patient results and see how AKLIEF (trifarotene) Cream, 0.005% helped improve acne and post-acne concerns.¹^abcd

Rapid, robust facial and truncal acne clearance

AKLIEF Cream is FDA approved to treat acne and clinically proven on both face and trunk.¹ In clinical studies, AKLIEF Cream reduced pimples, blackheads, and whiteheads, with visible improvements in acne as early as 2 weeks.²^ab AKLIEF Cream has been studied in patients with a range of skin tones and types.^2,3It has also been studied for its effect on acne scarring and acne-related dark marks.^4,5bcExplore real patient results and see what clearer-looking skin could look like with AKLIEF Cream.

Acne clearance on the face

Clinical studies showed that AKLIEF Cream reduced acne over time.² By Week 12, inflammatory acne lesions were reduced by up to 66%.^2ab

Images from a clinical study of people with facial acne treated with AKLIEF Cream.

Patients experienced improvements in acne severity, with more patients achieving clear or almost clear skin, along with reductions in acne lesions over time.^2c

Images from a clinical study of people with facial acne treated with AKLIEF Cream.

Patients experienced improvements in acne severity, with more patients achieving clear or almost clear skin, along with reductions in acne lesions over time.^2c

Images from a clinical study of people with facial acne treated with AKLIEF Cream.

Patients experienced improvements in acne severity, with more patients achieving clear or almost clear skin, along with reductions in acne lesions over time.^2c

View safety & tolerability data.

Truncal acne clearance

See before-and-after photos from clinical studies of AKLIEF Cream. AKLIEF Cream improved acne on the chest, shoulders, and back, with visible results seen as early as 2 weeks.²^ab By Week 12, truncal acne lesions were reduced by up to 65%.^2ab

Images from a clinical study of people with truncal acne treated with AKLIEF Cream.

Images from a clinical study of people with truncal acne treated with AKLIEF Cream. Patients experienced improvements in acne severity, with more patients achieving clear or almost clear skin as, along with reductions in acne lesions over time.^2c

Images from a clinical study of people with truncal acne treated with AKLIEF Cream.

Images from a clinical study of people with truncal acne treated with AKLIEF Cream. Patients experienced improvements in acne severity, with more patients achieving clear or almost clear skin as, along with reductions in acne lesions over time.^2c

Acne clearance and reduced acne scarring

Acne can leave behind lasting marks even after breakouts heal. In a clinical study, AKLIEF Cream helped improve active acne and helping to reduce the appearance of acne scars, with improvements in acne scars seen as early as 2 weeks.^4abc

Explore before-and-after results to see the impact AKLIEF Cream can have on both active acne and acne scars.

Images from a clinical study of people with facial acne and acne scars treated with AKLIEF Cream.

Images from a 6-month clinical study of people with acne and acne-related scarring. Patients using AKLIEF Cream experienced improvements in active acne, as well as reductions in the number and severity of acne scars over time.^4ad

Images from a clinical study of people with facial acne and acne scars treated with AKLIEF Cream.

Images from a 6-month clinical study of people with acne and acne-related scarring. Patients using AKLIEF Cream experienced improvements in active acne, as well as reductions in the number and severity of acne scars over time.^4ad

Images from a clinical study of people with facial acne and acne scars treated with AKLIEF Cream.

Images from a 6-month clinical study of people with acne and acne-related scarring. Patients using AKLIEF Cream experienced improvements in active acne, as well as reductions in the number and severity of acne scars over time.^4ad

Acne clearance and improved acne-related dark marks

AKLIEF Cream has been studied in people with acne-related dark marks, also known as post-inflammatory hyperpigmentation (PIH)*^cd. Visible reductions in dark marks were seen within 12 weeks, with continued improvement at Weeks 20 to 24.^5cd Explore before-and-after results to see the impact AKLIEF Cream can have on both active acne and the discoloration it can leave behind.

Images from a clinical study of people with facial acne and PIH treated with AKLIEF Cream.

Based on a clinical study evaluating AKLIEF Cream in people with acne-related dark marks, also known as post-inflammatory hyperpigmentation (PIH). Improvement in acne and PIH was observed over 6 months.^5be

Images from a clinical study of people with facial acne and PIH treated with AKLIEF Cream.

Based on a clinical study evaluating AKLIEF Cream in people with acne-related dark marks, also known as post-inflammatory hyperpigmentation (PIH). Improvement in acne and PIH was observed over 6 months.^5be

Images from a clinical study of people with facial acne and PIH treated with AKLIEF Cream.

Based on a clinical study evaluating AKLIEF Cream in people with acne-related dark marks, also known as post-inflammatory hyperpigmentation (PIH). Improvement in acne and PIH was observed over 6 months.^5be

Aklief and oral antibiotic combination

AKLIEF Cream can be used on its own or as part of a treatment plan with other acne medications, when recommended by your healthcare provider.⁶ In a clinical study of patients with severe acne, AKLIEF Cream used together with oral doxycycline delivered improvements over 12 weeks, with up to a 69% reduction in acne lesions.^7fab

Images from a clinical study of people with severe facial acne treated with AKLIEF Cream and oral doxycycline.

Results shown are from a 12-week clinical study of people with severe acne treated with AKLIEF Cream in combination with oral doxycycline. Patients experienced improvements in acne throughout the study period.^7f

Images from a clinical study of people with severe facial acne treated with AKLIEF Cream and oral doxycycline.

Results shown are from a 12-week clinical study of people with severe acne treated with AKLIEF Cream in combination with oral doxycycline. Patients experienced improvements in acne throughout the study period.^7f

Using AKLIEF Cream

*PIH, post-inflammatory hyperpigmentation

a. Studied in acne patients from 9 to 58 years of age with diverse skin types and moderate-to-severe acne. Nodulocystic acne was excluded from the trials.

b. Significant improvement seen as early as Week 1 in the pivotal clinical trials.

c. Secondary to clearing acne.

d. The primary endpoint was the overall disease severity score (ODS). No statistical significance between AKLIEF Cream and vehicle at Week 24 was seen.

References

AKLIEF® (trifarotene) Cream, 0.005% [Prescribing Information]. Dallas, TX: Galderma Laboratories, L.P.
Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol. 2019;80(6):1691–1699.
Blume-Peytavi U, et al. Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne. J Eur Acad Dermatol Venereol. 2020;34(1):166–173.
Schleicher S, et al. Trifarotene reduces risk for atrophic acne scars: Results from a phase 4 controlled study. Dermatol Ther (Heidelb). 2023;13(12):3085–3096.
Alexis A, et al. Efficacy and safety of trifarotene in acne-induced post-inflammatory hyperpigmentation. Int J Dermatol. 2024;63(6):806–815.
Reynolds RV, et al. Updated guidelines of care for acne vulgaris. J Am Acad Dermatol. 2024;90(5):1006.e1–1006.e30.
RD.06.SRE.202394 Clinical Study (DUAL study). Galderma. Data on file. Dallas, TX: Galderma Laboratories, L.P.

IMPORTANT SAFETY INFORMATION

Indication: AKLIEF^® (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Warnings/Precautions: Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning. Use a moisturizer from the initiation of treatment, and, if appropriate, depending upon the severity of these adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream. Minimize exposure to sunlight and sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.

Indication: AKLIEF^® (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Warnings/Precautions: Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning. Use a moisturizer from the initiation of treatment, and, if appropriate, depending upon the severity of these adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream. Minimize exposure to sunlight and sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.