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A CLEAR CHOICE in Acne Treatment

Many acne treatments, including topical retinoids, can make skin feel more sensitive at first.¹ This is common, and knowing what to expect can help you stay consistent with treatment over time.

Safety and tolerability 

AKLIEF (trifarotene) Cream, 0.005% is designed for daily use and is generally well tolerated.2,3 If irritation occurs, such as dryness, redness, peeling, or mild burning or stinging, it typically happens within the first 2 weeks and then gradually subsides as your skin adjusts.2,3
 

It is important to moisturize and use sun protection while using AKLIEF Cream.² See the tips below for starting treatment and supporting your skin as you adjust.

How to use AKLIEF Cream

Follow four simple steps: cleanse, treat, moisturize, and protect. Using AKLIEF Cream as part of a daily routine, along with gentle cleansers, moisturizers, and sunscreen, can help support treatment success while minimizing dryness and irritation.2,4
 

Cleanse

Wash your face twice a day, morning and evening. Use a mild or soap-free cleanser, then gently pat your skin dry.4

Treat

Once a day, in the evening, apply a thin layer of AKLIEF Cream to affected areas. Do not only spot-treat. A little goes a long way, and using too much may increase skin sensitivity.²
 

One pump is enough for the face, and two pumps can be used for the chest, shoulders, and back. An additional pump can be used for the mid-back.

Moisturize

To help minimize irritation, you can use a moisturizer before or after applying AKLIEF Cream. Moisturize as often as needed to help with dryness and irritation.2,4

Protect

Sunlight can make acne appear darker and last longer. Minimize exposure to sunlight and tanning beds. Use sunscreen and wear sun-protective clothing when outside.2

Step-by-step guide to using AKLIEF Cream

Using AKLIEF Cream as directed is an important part of your acne treatment journey.² Watch this video to learn how to incorporate AKLIEF Cream into your daily skincare routine. It includes tips for application, moisturizing, and sun protection to help support a positive treatment experience.2,4

Download Your Guide
AKLIEF Cream FAQs

References

  1. Zaenglein AL, Pathy AL, Schlosser BJ, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016;74:945–973.
  2. AKLIEF® (trifarotene) Cream, 0.005% [Prescribing Information]. Dallas, TX: Galderma Laboratories, L.P.
  3. Blume-Peytavi U, et al. Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne. J Eur Acad Dermatol Venereol. 2020;34(1):166–173.
  4. Reynolds RV, et al. Updated guidelines of care for acne vulgaris. J Am Acad Dermatol. 2024;90(5):1006.e1–1006.e30.

IMPORTANT SAFETY INFORMATION

Indication: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Warnings/Precautions: Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning. Use a moisturizer from the initiation of treatment, and, if appropriate, depending upon the severity of these adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream. Minimize exposure to sunlight and sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.