About AKLIEF® (trifarotene) Cream, 0.005%:

THE FIRST NEW RETINOID MOLECULE
FOR THE TREATMENT OF ACNE IN 20 YEARS.1

 

AKLIEF® (trifarotene) Cream, 0.005% product packaging. AKLIEF® Cream box next to its bottle against a purple background

AKLIEF Cream: AN INNOVATIVE APPROACH TO
ACNE CARE.

AKLIEF Cream is the first retinoid cream with
proven results in treating facial and truncal
acne vulgaris.1

THE IMPORTANCE OF RAR-γ IN THE TREATMENT OF ACNE VULGARIS.

In a study of human skin biopsies, the percentage of RAR found in the skin was2:

Magnified retinoic acid receptor-γ molecule represents AKLIEF® (trifarotene) Cream contains retinoids for acne treatment
87%

RAR-α (12-14%) and RAR-β (not detected) were significantly less prevalent.2

Targeting RAR-γ with retinoids for acne has several important functions in acne via gene modification2

  • Inflammation modulated via AP-12
  • Epidermal turnover and normalizing cell growth2
    • Keratinization
    • Desquamation

A UNIQUE ACNE TREATMENT DELIVERY SYSTEM.

AKLIEF Vehicle contains:
Molecule icon represents AKLIEF® (trifarotene) Cream Vehicle ingredient Simulgel® 600 PHA

Simulgel® 600 PHA6

  • Non-greasy
  • Allows for homogenous dispersion of active ingredients
  • Not sensitive to pH changes
Droplets icon reflects AKLIEF® (trifarotene) Cream Vehicle emollient ingredients Cyclomethicone & medium-chain triglycerides

2 emollients6-8

Cyclomethicone and medium-chain triglycerides allow for greater spreadability

Droplet entering skin icon represents AKLIEF® (trifarotene) Cream Vehicle ingredient Allantoin

Allantoin6,8

A known skin-conditioning agent and protectant

Leaf icon represents AKLIEF® (trifarotene) Cream Vehicle ingredient of being Paraben-free

Paraben-free6

Emollients are mostly lipids and oils which hydrate and improve skin softness, flexibility, and smoothness.11

PHA=(P)olysorbate 80, Iso(H)exadecane, and copolymer of (A)crylamide.

 

AKLIEF® (trifarotene) Cream, 0.005% MOA video thumbnail of magnified trifarotene molecules targeting rar-y skin receptors

AKLIEF Cream in action THE POWER OF PRECISION.

The first topical retinoid to specifically target RAR-γ, the most prevalent RAR in the skin.2,11

WATCH NOW

PROVEN EFFICACY IN TREATING
ACNE VULGARIS IN

2,000+

PATIENTS ENROLLED IN
2 CLINICAL TRIALS11

RAPID RESULTS.* POWERFUL
EFFICACY. EXCELLENT TOLERABILITY.11

View Clinical Data

*Indicates a 2-week time frame on both the face and the trunk.11

Teen female ready to return serve portrays confident patient using AKLIEF® (trifarotene) Cream prescription retinoid for acne

ACNE THAT'S BEYOND WHAT'S IN PLAIN SIGHT.

Patients with truncal acne may not freely talk about it with their doctors for various reasons. However, if left untreated, it can have a negative impact on their daily lives.6,10

WATCH NOW

References: 1. AKLIEF Press Release. Food and Drug Administration approval, 2019. 2. Fisher GJ, Talwar HS, Xiao J-H, et al. Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. J Biol Chem. 1994;269(32):20629-20635. 3. Aubert J, Piwnica D, Bertino B, et al. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor-γ agonist trifarotene. Br J Dermatol. 2018;179(2):442-456. 4. Czernielewski J, Michel S, Bouclier M, Baker M, Hensby JC. Adapalene biochemistry and the evolution of a new topical retinoid for treatment of acne. J Eur Acad Dermatol Venereol. 2001;15(suppl 3):5-12. 5. Goyette P, Chen CF, Wang W, Seguin F, Lohnes D. Characterization of retinoic acid receptor-deficient keratinocytes. J Biol Chem. 2000;275(22):16497-16505. 6. Del Rosso JQ, Bikowski JB, Baum E, et al. A closer look at truncal acne vulgaris: Prevalence, severity, and clinical significance. J Drugs Dermatol. 2007;6(6):597-600. 7. Parente ME, Gámbaro A, Solana G. Study of sensory properties of emollients used in cosmetics and their correlation with physicochemical properties. J Cosmet Sci. 2005;56(3):175-182. 8. Personal Care Products Council. Nikitakis J, Lange B, eds. International Cosmetic Ingredient Dictionary and Handbook. Vol. 1. 16th ed. Washington, DC: 2016. (299,65). 9. Sethi A, Kaur T, Malhotra SK, Gambhir ML. Moisturizers: The slippery road. Indian J Dermatol. 2016;61(3):279-287. 10. Mandy SH. Chest and back acne: A retrospective review. Adv Ther. 1995;12(6):321-332.11. Tan J, Thiboutot D, Popp G, et al. Randomized phase 3 evaluation of trifarotene 50 µg/g cream treatment of moderate facial and truncal acne. J Am Acad Dermatol. 2019;80(6):1691-1699.

IMPORTANT SAFETY INFORMATION

Indication: AKLIEF® (trifarotene) Cream, 0.005% is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older. Adverse Events: The most common adverse reactions (incidence ≥ 1%) in patients treated with AKLIEF Cream were application site irritation, application site pruritus (itching), and sunburn. Warnings/Precautions: Patients using AKLIEF Cream may experience erythema, scaling, dryness, and stinging/burning. Use a moisturizer from the initiation of treatment, and, if appropriate, depending upon the severity of these adverse reactions, reduce the frequency of application of AKLIEF Cream, suspend or discontinue use. Avoid application of AKLIEF Cream to cuts, abrasions or eczematous or sunburned skin. Use of “waxing” as a depilatory method should be avoided on skin treated with AKLIEF Cream. Minimize exposure to sunlight and sunlamps. Use sunscreen and protective clothing over treated areas when exposure cannot be avoided.

 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

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